The development rule of type 2 diabetes
Type 2 diabetes, including islet dysfunction and insulin resistance in two ways.
Islet dysfunction in type 2 diabetes is characterized by islet
β-cell damage is minor damage from the gradual increase, the ability to
secrete insulin gradually decreased.
Insulin resistance is the body's liver, muscle, fat tissue cells
such as the role of insulin resistance, so that insulin can not
properly play its role. Manifested in two aspects: the ability of
insulin to transmit blood glucose and insulin to reduce the inhibition
of hepatic glucose output decreased.
The role of insulin receptor-deficient so that the effectiveness
of fall - can not be successfully opened the glucose-insulin-channel,
glucose can not be successfully enter into the cells, which is the
so-called insulin resistance.
The second aspect of insulin resistance is manifested in the
liver: insulin on hepatic glucose output has in vitro. Under normal
circumstances, when blood sugar rises, insulin secretion increased, so
the inhibition of liver glucose output. But when there is "insulin
resistance", the insulin regulation of hepatic glucose output
"failure", it can not effectively suppress hepatic glucose output.
Insulin resistance is characterized by abnormal elevation of the
need for insulin. Increase the extent of your requirements and the
amount of insulin, insulin resistance and islet function.
About 70% ~ 90% in patients with type 2 diabetes is insulin
resistance and insulin secretion by the lack of double factors. Insulin
resistance is the "cause" injury of islet function is "fruit." No islet
dysfunction, how much insulin, islet function will give you the number
of insulin secretion, they will not get diabetes. Insulin secretion can
not be long-term, unlimited increase in insulin secretion will
eventually reach the limit and can not continue to increase. If the
long-standing insulin resistance, pancreatic functional reserve will
vanish; and because of pancreatic islet β-cells secrete insulin will
not be able to meet the needs of the body to insulin increases continue
to increase indefinitely, that is, can not meet the needs of the body.
Emergence of the "relative lack of insulin" - the body's insulin levels
higher than normal, but excessive insulin need, has been inadequate,
and blood sugar will rise. With the extension of course, the damage
islet function will become increasingly heavy secretion of insulin
would be less and less, it appears the lack of insulin - your insulin
levels even lower than normal.
The law of development of type 2 diabetes:
(1) insulin resistance phase: the so-called insulin resistance is
the organization of the body less sensitive to insulin. The body to
maintain normal blood sugar, the need for more insulin than normal, the
body will be through the use of the reserve part of the islet to
produce more insulin, which is the so-called hyperinsulinemia.
(2) islet dysfunction stages: a gradual increase of this damage
process. Effect of early pancreatic islet dysfunction light, the lack
of insulin effect of light, the secretion of insulin in some states can
meet the body's needs. As the disease worsened islet dysfunction
gradually worsened, the secretion of insulin the body will not be able
to meet the needs of a variety of state, performance has continued to
rise for the fasting blood glucose.
(3) islet failure stages: pancreatic β-cells, further serious
damage, failure will be developed to the stage. The body would be a
serious lack of insulin, if not timely replenishment of exogenous
insulin, it will endanger human life.