A new future treatment of type 1 diabetes

U.S. researchers on human blood cells, a study shows that the successful suppression to help control the immune system, a metabolic pathway can kill attacking immune cells in a patient's own organization, which is expected to become a new diabetes therapy.
 
Massachusetts General Hospital researchers looked at 1,000 type 1 diabetes, other autoimmune patients and healthy controls were abnormal T-cells. The researchers carried out before the show can effectively reverse type 1 diabetes rat model strategy. The strategies include stimulating the immune system modulator of tumor necrosis factor (TNF) expression, the factor and attacks insulin-producing islet T-cell death-related.
 
In human studies, TNF treatment can lead to CD8 anti-T cell death, but will not affect the CD4-assisted T cell, TNF can also lead to other autoimmune diseases in patients with CD8 T cell death, but had no effect on healthy controls. The researchers also found that, TNF receptor 2 (TNFR-2) agonists have similar activity, further studies have shown that, TNFR-2 agonists and can lead to diabetes in patients with pancreatic islet cell destruction CD8T death, but in non-diabetic patients can be so that similar cell proliferation. It is noteworthy that act on the common virus targeting CD8 T cells are not subject to TNFR-2 agonist effects.


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